Title Page Section: THROMBOSIS AND HEMOSTASIS Title: Cartilage Oligomeric Matrix Protein is a Natural Inhibitor of Thrombin
نویسندگان
چکیده
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University; Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, P. R. China; The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Ministry of Health, Beijing, P. R. China; Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China; Department of Biophysics, School of Basic Medical Sciences, Peking University, Beijing, P. R. China; and Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai, P. R. China.
منابع مشابه
Cartilage oligomeric matrix protein is a natural inhibitor of thrombin.
Thrombin is an effector enzyme for hemostasis and thrombosis; however, endogenous regulators of thrombin remain elusive. Cartilage oligomeric matrix protein (COMP), a matricellular protein also known as thrombospondin-5, is essential for maintaining vascular homeostasis. Here, we asked whether COMP is involved in the process of blood coagulation. COMP deficiency shortened tail-bleeding and clot...
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